21-Jul-06

Stem Cells

While the Isreal-Lebanon conflict is obviously generating the lion's share of the news headlines here (along with the collapse of one of the ceiling panels on one of the "Big Dig" tunnels, a $15 billion project to bury all the expressways in downtown Boston, which killed one woman), Bush's decision to veto legislation giving federal money to embryonic stem cell research has also generated a lot of buzz.  This is particularly true in my scientific circle, since the lab I just joined is one of the relatively few labs in the U.S. which conducts this kind of research (although I will not be a part of it, by choice).  Only Massachusetts, Michigan, and California provide state funding for embryonic stem cell research - anywhere else, it's not illegal but nobody will give you money to do it, which practically shuts the research down.

This is one issue I have very mixed feelings about.  There are very valid scientific reasons why embryonic stem cells offer vast potential to fix a lot of problems.  One of the big pushes in bioengineering now is the growth of replacement organs - that is, instead of doing temporary patches while waiting for a human donor organ, the goal is to actively grow the different tissues comprising the heart by giving a stem cell (the ultimate "parent cell" type of all the cells in our body) the correct stimuli to "decide" which tissues to make and how to put them together.  This is essentially what happens during the development of a baby and is not nearly as science fiction as it sounds.  Indeed, right now (and using fairly unsophisticated techniques), we can grow simple organs (like the ear) fairly successfully in mice.  While embryos aren't the only source of stem cells, they are by far the least differentiated and thus the easiest to manipulate.  That means that while a mesenchymal stem cell (the next best kind of stem cell, from bone marrow) might be signalled to produce some of the different tissues in the bone or many blood cells, it wouldn't be able to produce lung tissue.  Embryonic stem cells are further back in deciding what they want to be "when they grow up", so they are easier to influence (kind of like McDonalds advertising Happy Meals to 3-year-olds).  So, as a scientist, I understand why people want to do this work - it makes sense and it may well work in quite amazing new ways.  The argument that the embryos the scientists want are simply slated for destruction anyway (if the parents don't want/need the embryos) is also somewhat compelling.  Why destroy something that may be used to impart very significant improvements in human health?  

However, here's where I think this whole debate is totally missing the boat.  Somehow, without any significant public debate, we have allowed 400,000 embryos (which have already been developed for up to six days prior to being frozen so that the in vitro fertilization doctors can select the "best" of the fertilized eggs to implant to maximize the chance for a successful pregnancy) to be put into storage.  If these embryos are deemed to be "unneeded" for pregnancy (a likely result if the couple chooses not to have additional children), all of these embryos are effectively marked for disposal , at least in the long term.  So, in a sense, the stem cell debate isn't about whether or not to kill embryos; it's more about how and when to kill them.  Or, put in another way, this embryo debate has effectively already been settled while nobody was paying attention.  While I would still personally refuse to do embryonic stem cell research since I believe that embryos are "humans" (that is, they contain everything required to form a human being), stem cell research may in fact be the best of two bad solutions to the embryo stockpile.

Posted by Todd at 00:58:18 | Permanent Link | Comments (3) |
Comments
1 - Hey Todd,

Can you expand on the scientific aspects of why you consider a stem cell to be "human"? This is an issue that I've always felt was a bit over my head so maybe you can help explain it to me? (Comment this)

Written by: Jason at 2006/07/31 - 06:03:03
2 - Hi Todd:

In your blog you have mirrored my own concerns about the whole stem cell debate. At conception the whole genetic code that defines a physical human being is assembled. This is such a unique point in a person's development that I cannot with any degree of certainty pinpoint another more significant time when a person can be said to become human. Given that analysis, deliberately creating and killing embryonic stem cells means we have crossed a line that I believe should not be crossed. Yet in counter balance to that, who am I to deny potenital aid to someone who is desperately ill?

I guess, as I struggle with these opposing duties, I am compelled to oppose embryonic stem cell research, but I can't bring myself to oppose it as strongly as I oppose abortion on demand.

Peter
http://www.PeterKazmaier.com (Comment this)

Written by: Peter Kazmaier at 2006/07/31 - 13:02:12
3 - Jason - I think about this issue sort of in parallel to a computer program (cue geeky engineer explanation). With just an egg and sperm, you really have a program which contains a bunch of code but can't do anything - the individual lines of code are themselves useful but the program as a whole just doesn't work. However, when the egg is fertilized and an embryo is formed, it's like completing the computer program - the full set of instructions for forming a human being is now present. All you need is the hardware (the computer) and the power (the electricity) to make the program do what it is intended for - in the case of an embryo, the environment for growth and the required nutrients. So, in my opinion, the moment the computer program (the genetic code) is completed and the "run" button is pressed (which it has been in these embryos, which have already been growing up to six days prior to being frozen), the essence of "humanness" is achieved, since all that's left to do is to let the program do its thing to generate the output. That is why I would argue an EMBRYONIC stem cell is a human. That being said, the term "stem cell" simply refers to cells which have not been completely differentiated yet - that is, single cells which can still be chemically signaled to produce different kinds of cells. I have absolutely no objection to using stem cells from any other source (which indeed are present in all of our bodies right now in the roots of hair, the bone marrow etc.) since these cells are not programmed to become complete humans, simply a skin cell or a muscle cell. Hopefully that helps.

Peter - I totally agree with your assessment. I find it hard to drum up much passion opposing stem cell research when I can see the real potential benefits of doing the research AND I see that 400,000 embryos are essentially slated for destruction anyway. (Comment this)

Written by: Todd at 2006/08/01 - 00:34:56
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